My wife has had MS for nearly 30 years. She has suffered urinary incontinence to one degree or another for a long time. Unfortunately for the last 3 or 4 years. She is in the advanced cruel stages of the disease. Mostly confined to bed or Her wheelchair. Dependent on caregivers or Me. For pretty much everything. Including changing Her adult diapers. Every morning one of the firsts tasks is to change Her. After We get Her out of bed and into Her chair. Usually by mid to late morning its time to change Her again. Then at some point in the afternoon. Then usually after dinner. And then once before bed. We use the tranquility overnight diapers most of the time. They are more expensive. But it helps to keep the urine off Her skin for a couple of wettings. Unless Her bladder has a extra heavy void. So 5-6 changes a day. Infusion days can be worse.